Tfrc hif
WebDisease relevance of Tfrc. On the contrary, increased transcription of the TfR gene in isolated nuclei was observed during reperfusion; during the ischemic phase this was preceded by enhanced binding of hypoxia inducible factor (HIF-1) to a DNA sequence derived from the TfR promoter . WebTFRC is associated with suppressive tumor immune microenvironment and poor prognosis for HCC. A TFRC mRNA expression in 33 types of TCGA tumors. B Kaplan-Meier curves for overall survival...
Tfrc hif
Did you know?
Web12 Sep 2024 · We also confirmed similar effects of ISCA2 knockdown in decreasing HIF-1/2α, IRP1, IRP2 and TFRC in RCC4 cells which are pVHL deficient, suggesting that ISCA2 … WebIn addition, the transferrin receptor gene (TFRC) is also a target common to both MYC and HIF 73,74. TFRC could also be inhibited by small molecules, leading to growth inhibition 75,76.
WebTfR1 = transferrin receptor 1 in Human iron metabolism. TfR1 is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. Each monomer binds one holo- transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis. [9] Clinical significance [ edit] WebSYSTEMIC IRON DEFICIENCY AND INTESTINAL INFLAMMATION CONTROL GUT MUCOSAL HIF-1? AND TFRC ACTIVATION IN INFLAMMATORY BOWEL DISEASE Arno R. Bourgonje 1 …
Web30 May 2006 · When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). By similarity. 3 publications (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. 2 publications. Web1 Jun 2024 · Differential gene expression of (D) HIF1A and (E) TFRC in ileal biopsies from non-inflamed (blue dots) and inflamed (red dots) areas, according to iron deficiency status of IBD patients at moment ...
WebClinical data analysis showed that high TFRC expression in cervical cancers was associated with incrementally advanced stage, tumor status, and lymph nodes (all p-values <0.05), …
WebBy performing Spearman correlation analysis between mucosal TFRC gene expression levels and serum free iron levels of the same patients, we observed that intestinal mucosal TFRC expression was not ... homewood doctorsWebHigh TFRC expression is associated with response to low intravenous immunoglobulin therapy in patients with Kawasaki disease. ... Transfection of cDNA expressing stable form of HIF-1alpha reversed the increased TfR1 expression and iron uptake. These results suggest a novel role of insulin in hepatic iron uptake by a HIF-1 dependent ... histoire meaningWeb23 Jan 2024 · Background Transferrin receptor 1 (TfR1), encoded by TFRC, is a key regulator of iron homeostasis and plays important roles in many diseases, including cancers. … homewood disposal service pay billWebincreasing TFRC-mediated iron absorption in non-inflamed tissue and 2) decreasing mucosal inflammation, thereby improving their responsiveness to oral iron supplementation. homewood downtown austinWebIn addition, the transferrin receptor gene (TFRC) is also a target common to both MYC and HIF 73,74. TFRC could also be inhibited by small molecules, leading to growth inhibition … homewood dominican republicSurprisingly, we discovered that TFRC-involved HIF-1 signaling pathway is strongly associated with human cervical cancer. As known, under certain circumstances like oxidative stress, inflammation ... homewood disposal tinley park ilWeb04066 HIF-1 signaling pathway 7037 (TFRC) 09140 Cellular Processes 09141 Transport and catabolism 04144 Endocytosis 7037 (TFRC) 04145 Phagosome ... 7037 (TFRC) CD … homewood downtown dallas